CHANGES IN THE ORAL MUCOSA AND SPECIFIC CLINICAL SIGNS IN PATIENTS WITH RECURRENT APHTHOUS STOMATITIS

Abstract

Modern social and medical studies show that in the health of the human population (including the dental), in recent decades, unfavorable trends persist. Despite numerous studies, both in our country and abroad, the etiology and pathogenesis of recurrent aphthous stomatitis remains unclear to the end. A significant increase in the prevalence of recurrent aphthous stomatitis, affecting from 20 to 60% of the population, is drawing attention to this serious problem of practical dentistry. Over the past 15 years, scientists around the world have done a great deal of research into the etiopathogenesis, prevalence, intensity of the course of RAS and have proposed various methods of treating this disease [1,3,5]. But in the end, it has not been conclusively established which factors contribute to the development of this disease, and which play a dominant role in the pathogenesis of RAS. Therefore, despite the large number of studies devoted to the etiopathogenesis of RAS, an additional research method for this pathology has not been developed. Moreover, there are certain contradictions in the interpretation of research results [2,7]. The etiology and pathogenesis of chronic recurrent aphthous stomatitis have not been fully elucidated. It has been established that a significant role in the pathogenesis of chronic inflammatory processes belongs to the state of the microbiocenosis of the oral mucosa [4,5]. His participation in the processes of metabolism, vitamin synthesis, the formation of immune status and non-specific resistance has been proven.