THE STATE OF THE MUCOUS MEMBRANE OF THE NASAL CAVITY IN PATIENTS WITH CHRONIC RENAL FAILURE

Abstract

An increased tendency to bleed in patients with renal insufficiency may present clinically with gastrointestinal bleeding, retinal hemorrhage, subdural hematoma, epistaxis, hematuria, ecchymosis, purpura, gingival bleeding, gingival bleeding, genital bleeding, hemoptysis, telangiectasias, hemarthrosis, and petechiae. Interestingly, hemodialysis itself may predispose to bleeding disorders, not only due to the heparin administered, but also due to the constant activation of platelets on the dialyzer membrane, followed by a decrease in dialyzer activity. In contrast, hemodialysis has been shown to reduce platelet abnormalities, resulting in a reduced risk of bleeding due to the removal of uremic toxin. In patients with renal insufficiency, anemia directly affects bleeding time. The erythrocytes lead to the accumulation of platelets along the walls of blood vessels in the bloodstream, together with stimulation of the release of platelet ADP and inactivation of PGI2, thereby activating platelet function. Nasal septal perforation in patients with uremia may occur due to trauma to nasal catheters and impaired proliferation of mucosal cells. In addition, disturbances in the innervation of the vessels of the nasal septum due to neuropathy of the autonomic nervous system and ischemia secondary to narrowing of the arterioles may play a certain role.