THE EFFECT OF GOSSYPOL DIAZOIMINO DERIVATIVES ON THE HIGH CONDUCTIVITY PORES OF HEART MITOCHONDRIA IN EXPERIMENTAL MYOCARDIA

Abstract

In recent studies it is proved that mitochondria plays a major role in cardiomyocyte function, regulation of apoptosis and cell necrosis [1]. The functional activity of mitochondria depends on the activity of many ion channels, and the physiological importance of the megapore ( mPTP -mitochondrial permeability transition pore ) is very important. MPTP is a channel that physiologically regulates the release of Ca2+ ions from the mitochondrial matrix and is involved in the homeostasis and signaling of Ca2+ ions between the cell cytosol and the matrix during the normal life of cells [6]. Mitochondrial megapore ( mPTP ) is a channel that passes through the outer and inner membranes of mitochondria and it is consists of potential-dependent anion channel ( VDAC ), adenine nucleotide translocase (ANT) and cyclophilin D protein [3] . Mitochondrial megapores have an active conduction and they are highly permeable to Ca2+ and in the cell show an active conformation when the charge of ions increases, regulate the homeostasis of ions in the matrix and thus the control of metabolic processes [2]. Experimental studies have shown that an increase in the amount of Ca2+ in the mitochondria , which in turn stimulates the opening of mRTR, and the release of Ca2+ ions from the mitochondria, correspondingly, leads to the entry of H+ ions into the mitochondrial matrix [4]. A sharp increase of permeability of mitochondrial megapore is observed in certain pathological conditions such as ischemia, neurodegenerative diseases, toxic hepatitis, diabetes mellitus and various hypoxic conditions[5]. It is known that the cardioprotective value of bioactive substances that inhibit the state of cardiac mPTP is high in myocarditis and is currently being widely studied in research.